Abstract: Objective To develop general practice and train general practitioners is an important part of establishing a hierarchical medical system in line with China's national conditions, accelerating the development of medical and health services, and deepening the reform of medical and health services. Methods This paper summarizes the experience of general practice resident standardized training and general practice trainner training in general practice base of the first affiliated hospital of Sun Yat-sen university First, We adopted the training management mode of "coordination between medical and education" "three-ring management" and "linkage up and down" in the standardized training of general residents, emphasized on humanistic education, actively used social resources to improve the level of diagnosis and treatment of regional general practitioners and adopted the tutor responsibility system to train the high level professional scientific research ability of general practitioners to achieve the unity of five certificates. Secondly, we enriched clinical teaching methods and improved clinical teaching skills through the clinical teacher-funded curriculum training system, and signed a cooperation agreement with the university of Birmingham to set up the "Guangzhou-Birmingham medical consortium" to conduct personalized teaching and convey the educational concept of "self-oriented learning". In addition, 5-year clinical medicine undergraduates were offered the course to introduce the general medicine. The combination of theoretical teaching and community hospital internship enables medical students to have a perceptual and rational understanding of the concept, work nature and practical application of general practice. Results We have set up a special training base for general practitioners and built a team of high-quality general practitioners with teacher resources for south China and aroused the interest of medical undergraduates to train future general practitioners for society. Conclusion Through our efforts, we shall build high-quality general practice bases and train more general practice talents for the country.