Abstract: Objective To explore and analyze the correlation between blood uric acid and carotid atherosclerosis in patients with cerebral infarction. Methods A total of 90 patients with acute cerebral infarction in our hospital from January 2016 to July 2018 were enrolled as the research participants. General data were recorded. All patients were examined by carotid artery color Doppler ultrasonography. According to the presence and stability of plaque, they were divided into three groups: stable plaque group, unstable plaque group and non-plaque group. The blood uric acid level and C-reactive protein level related indicators in different group were measured, and the effect of uric acid on plaque formation was analyzed. Results There were significant differences in serum uric acid levels among the three groups (P<0.05) with significant difference between the non-plaque group and the stable plaque group and the unstable plaque group (all P<0.05). There was no significant difference between stable plaque group and unstable plaque group (P>0.05). There were significant differences in C-reactive protein levels among the three groups (P<0.05), among which there were significant differences between the non-plaque group and the stable plaque group and the unstable plaque group (all P<0.05); there was no difference between the stable plaque group and the unstable plaque group (P>0.05). Conclusions The level of hyperuricemia in patients with acute cerebral infarction is closely related to the occurrence of carotid atherosclerotic plaque, but the stability of carotid atherosclerotic plaque has no significant correlation with the level of serum uric acid. The elevated serum uric acid level suggests that patients have the risk of carotid atherosclerosis plaque formation. Clinically, appropriate intervention can be given in time according to the serum uric acid level.