Abstract: Objective Investigate the effect of standardized pain management on preoperative application in patients with osteoporotic vertebral compression fractures. Methods Patients with osteoporotic vertebral compression fractures were divided into two groups according to the patient's admission time. The 50 patients admitted from February to November 2017 were the control group, and 50 patients admitted from December 2017 to July 2018 were the observation group. There was no statistical significance on the difference of patients' gender, age, fracture segment and pain at admission between the two groups. All 100 patients were treated with Percutaneous vertebroplasty (PVP). The control group was treated with the routine pain care, giving health education, psychological counselling, pain assessment, non-drug care intervention, and drug analgesia. The observation group used standardized pain care, which assessed the patient's pain and recorded objectively and accurately, enhancing pain education and psychological care, advanced analgesia, timely analgesia, individualized analgesia and multimodal analgesia. Compare the pain care quality and analgesic effect of the preoperative pain intervention in two groups. Results There was statistical significance between the preoperative pain status of the two groups, the number of cases of intramuscular injection of analgesic drugs, the degree of pain affecting sleep, the degree of pain knowledge and the adequacy of pain selection methods, and the satisfaction of pain control, with statistical significance (all P<0.05). In contrast, there was no significant difference in the effect of pain on the turn-over between the two groups and the pain intensity recorded by digital assessment or descriptive method (all P>0.05). Conclusion The implementation of standardized pain management is helpful to improve the quality of preoperative pain care and analgesia in patients with osteoporotic vertebral compression fractures.