Abstract: Mild cognitive impairment(MCI) is now a common condition in older people. It's a clinical condition between normal aging and mild dementia. Therefore, early intervention for mild cognitive impairment to improve cognitive decline and delay its transition to dementia is particularly important. In recent years, people around the world have been exploring ways to better prevent and treat MCI through drug and nutrient intervention, physical exercise, life behavior intervention and cognitive training. Whether those drugs and nutrients that can prevent and control the risk factors of mild cognitive impairment can be used in the prevention stage of MCI is worthy of attention and needs further research and confirmation. This paper will expound the research on the treatment of mild cognitive impairment drugs and nutrients in recent years, providing a basis for further exploring the drug treatment of mild cognitive impairment.