Abstract: Objective To explore the expression of EGFR, c-Met, PDGFR and VEGFR in gastric cancer tissues and its prognostic significance. Methods One hundred and eighteen cases gastnic cancer patients in our hospital between January 2012 to August 2015 were selected. The levels of EGFR, c-Met, PDGFR and VEGFR in gastric cancer tissues were tested. The clinical and pathological differences among the patients with different levels of receptor tyrosine kinase were studied. The influence of the levels of receptor tyrosine kinase was evaluated. Results No significant difference in tumor location, diameter and pT stage were found between EGFR positive and negative group (all P>0.05), while the differentiated degree of cells was significantly lower and pN stage was significantly high in EGFR positive group (all P<0.05). No significant difference in tumor location and tumor diameter were found between c-Met positive and negative group (all P>0.05), while differentiated degree of cells was significantly lower, pT and pN stag were significantly higher in c-Met positive group (all P<0.05). No significant difference in tumor location, differentiated degree, tumor diameter and pT stage were found between PDGFR positive and negative group (all P>0.05), while pN stage was significantly higher in PDGFR positive group (P<0.05). No significant difference in tumor location, differentiated degree and diameter were found among VEGFR positive and negative group (all P>0.05), while pT and pN stage were significantly higher in VEGFR positive group (all P<0.05). The death risk of negative group of these four index were significantly lower than the matching positive group (all P<0.05). pT stage and pN stage were risk factors for bad prognosis of gastric cancer. Conclusion The positive expression of EGFR, c-Met, PDGFR and VEGFR may result in a bad prognosis. pT stage and pN stage are the risk factors for bad prognosis of gastric cancer.