Abstract: Objective In this study, a self-made rehabilitation program was used in elderly patients with obstructive sleep apnea hypopnea syndrome (OSAHS), and analyzed the results of application, in order to improve the treatment compliance and prognosis of patients. Methods A total of 106 patients with OSAHS who were treated in our hospital were selected from September 2016 to August 2018, and they were randomly divided into observation group (n=53) and control group (n=53) according to the random number table method. The patients in the control group received routine nursing, while the patients in the observation group received rehabilitation program. The sleep quality, daytime sleepiness and patient satisfaction were compared between the two groups. Results Before implementation, there was no significant difference in sleep quality index between the two groups (P>0.05), one month after implementation, the sleep quality score of the observation group was 6.68±2.31, and the sleep quality score of the control group was 12.65±3.57, the sleep quality indices of the two groups were significantly lower than those before implementation (P<0.05), and the sleep quality index of the observation group was significantly lower than that of the control group (P<0.05). Before implementation, there was no significant difference in daytime sleepiness score between the two groups (P>0.05), one month after implementation, the sleepiness score of the observation group was 8.56±2.12, and that of the control group was 15.74±2.54, the daytime sleepiness scores of the two groups were significantly lower than those before the implementation (all P<0.05), and the daytime sleepiness score of the observation group was significantly lower than that of the control group (P<0.05). The patient satisfaction of the observation group was 94.34% (n=50), while that of the control group was 73.58% (n=39), the patient satisfaction of the observation group was significantly higher than that of the control group (P<0.05). Conclusion Rehabilitation program has achieved good results in the application of elderly patients with OSAHS, it can effectively improve the sleep quality, reduce daytime sleepiness, and improve patient satisfaction, the program helped to improve patients' treatment compliance and prognosis.