Abstract: Objective To analyze the influence of lifestyle management on the therapeutic effect of adolescent polycystic ovary syndrome (PCOS) patients, and to provide evidence for improving the therapeutic effect of adolescent PCOS patients from the perspective of lifestyle management. Methods A total of 112 adolescent patients with polycystic ovary syndrome (PCOS) from March 2017 to February 2018 were enrolled in this study. Lifestyle management and drug therapy were carried out. After six months, the mean scores of the five dimensions of the self-rating scale for lifestyle of patients with PCOS were divided into high score group and low score group. The levels of testosterone, ovarian volume, BMI, hirsutism and acne were compared between the high and low score groups, and the effects of different lifestyles management on the treatment effect of adolescent polycystic ovary syndrome were analyzed. The data were analyzed by SPSS 19.0 statistical software. Results The testosterone level, ovarian volume, body mass index and Rosenfield score of the low score group of dietary rhythm, dietary content, body constitution awareness and life rhythm were lower than those of the high score group. The testosterone level, ovarian volume, body mass index and Rosenfield score of the high score group of exercise awareness were lower than those of the low score group, the difference was statistically significant(all P<0.05), However, there was no significant difference in F-G scores between the high and low scores of the five dimensions of the self-rating scale for lifestyle of patients with polycystic ovary syndrome(all P>0.05). Conclusion Good lifestyle plays an active role in promoting the therapeutic effect of adolescent patients with polycystic ovary syndrome, reducing testosterone level, ovarian volume, weight control and acne symptoms, but has little effect on hirsutism.