Abstract: Objective To study and explore the clinical efficacy of brain function therapy combined with psychological intervention in elderly patients with medication overuse headache (MOH). Methods From July 2014 to July 2015, 120 patients were diagnosed as MOH patients in the department of cadre's ward and department of neurology. The patients were divided into observation group and control group according to the random number table method, with 60 cases in each group. The control group was treated with nifedipine and nimodipine nimodipine (30 mg tid) prophylactic treatment, based on which the observation group used YS7004 brain function treatment and psychological intervention comprehensive treatment. After four weeks treatment, VAS score, headache attack frequency and serum basic fibroblast growth factor (bFGF) concentration in the two groups before and after treatment were evaluated to compare the level of headache, the SAS and the SDS to assess the patient's mental state, compared to the health survey scale (SF-36) to assess the quality of life of patients. Results ①The VAS score, the frequency of headache and the level of serum basic fibroblast growth factor (bFGF) in the two groups were lower than those before treatment, and the decrease rate of the observation group was better than that of the control group, with statistical significance (P<0.01). ②The scores of SAS score and SDS before and after treatment were significantly different from those before treatment (P>0.05). The SAS score and SDS score of the observation group were significantly lower than those before treatment (P<0.01). ③After treatment, SF-36 scores were significantly higher than those before treatment, and the observation group was more significant, showing statistical significance (P<0.01). Conclusion On the basis of routine treatment, combined with brain function therapy instrument and psychological intervention therapy, it has a more significant effect on elderly patients with medication overuse headache, which can relieve headache, improve anxiety and depression, and improve the quality of life of patients.