Abstract: Objective To investigate the clinical efficacy of Dexmedetomidine for sedation in tangential excision and skin grafting for burn treatment. Methods A total of 60 hypertension patients with burns undergoing tangential excision and skin grafting in our hospital from January 2014 to December 2017 were enrolled into this study and randomly divided into control group and treatment group with 30 patients in each group. All the selected patients were administrated with 0.5 mg penehyclidine hydrochloride intravenously 20 minutes before surgery. The control group received the routine surgical anesthesia, while the treatment group received intravenous injection of dexmedetomidine 15 min before the surgery on the basis of routine anesthesia. Results The level of sedation scores at 10 minutes after induction in the treatment group was higher than that in the control group, the oxygen saturation in the treatment group was lower than that in the control group, however, the respiratory rate in the treatment group was higher than that in the control group, the differences were statistically significant (all P<0.05). The maintenance dose of propofol per unit time was (3.9±0.8) mg/ (kg·h) in the control group, and (1.7±0.4) mg/ (kg·h) in the treatment group, of ketamine was (3.5±0.6) mg/ (kg·h) in the control group and (1.4±0.3) mg/ (kg·h) in the treatment group, respectively, the difference was statistically significant (all P<0.05). During the excision of the scab, skin harvest and skin grafting, the heart rate and systolic blood pressure in the treatment group was significantly lower than those in the control group, and the difference was statistically significant (all P<0.05). The incidence of adverse reactions in the treatment group was significantly lower than that in the control group, the l wake-up time after surgery was significantly shorter than that in the control group, and the differences was statistically significant (all P<0.05). The surgery duration of the control group and the treatment group were (151.6±71.3) min and (161.8±69.3) min, respectively, with no significant difference (P>0.05). Conclusion The intravenous infusion of dexmedetomidine can save the dose of propofol and ketamine on the base of sedation. The hemodynamics and respiration of the patients keep stablely during the operation. It can also shorten the waking-up time and decrease the incidence of adverse reaction.