Abstract: Objective To describe the status of self-perceived burden and analyze its influencing factors among the patients with head and neck tumor for radiotherapy, providing for a scientific basis to alleviate the psychological pressure and improve patients' quality of life. Methods From October 2016 to August 2017, a total of 108 hospitalized patients with head and neck tumor for radiotherapy were investigated by the Self-Perceived Burden Scale and the self-designed general scale, and analyzed by using univariate and multivariate to determine the influencing factors of patients with head and neck tumor for radiotherapy. To ensure the survey is rigorous and scientific, we took uniform training. Results The total score of the SPB was (33.35 ±6.34) points, 56.5% of patients were at a moderate level. Among them, the top three were worried that caregivers spend a lot of money worrying about the caregiver's health due to taking care of me, and worrying that the caregivers were overburdened by taking care of me. Univariate and multiple linear regression analysis showed that gender, marriage, personality, education level, the number of radiotherapy, radiotherapy response, and concurrent with chemotherapy were the factors influencing factors of SPB (P < 0.05). Conclusion The SPB of head and neck cancer patients with radiotherapy is at a moderate level. To reduce the burden of patients with self-perception and improve their quality of life, we should focus on the SPB of patients with radiation therapy, according to the patient's gender, marriage, personality, education level, radiotherapy and other related factors to take targeted care intervention.