Abstract: Objective To explore the application methods and effect of clinical nursing pathway (CPN) applied in the artificial liver plasma exchange (PE). Methods From March, 2014 to November, 2016, 80 Liver failure patients with artificial liver plasma exchange were randomly divided into experimental group and control group, with 40 cases in each group. Patients in experimental group were treated with clinical nursing pathway, while patients in control group were treated with routine nursing. The satisfaction, the qualification rate of health education, the complication rate, and the effective rate were observed in both groups. All the data were analyzed with SPSS 17.0. A descriptive analysis of the percentage and rate of the data was used, and chi-square test was used, with P<0.05 indicating statistical significance. Results The satisfaction and the qualification rate of health education in experimental group were 85% and 90%, significantly superior to 55% and 65% of the control group (P=0.003, P=0.007). The complication rate in experimental group was 12.5%, inferior to those of the control group (35.0%, P=0.018). The treatment efficacy rate was 80% in the experimental group and 72.5% in the control group, without statistical significance (P=0.431). Conclusion Application of clinical nursing pathway improves patients' satisfaction and qualification rate of health education, and reduces complication rate.