Abstract: Objective To explore the effect of different liquid resuscitation strategy on the complications and prognosis of patients with hemorrhagic shock. Methods We selected 120 cases of with hemorrhagic shock in our hospital from January, 2015 and June, 2016 as the research object, divided them into observation group(60 patients) and control group(60 patients) by random number table method. The patients in the observation group were given a limited fluid resuscitation, and the patients in the control group received traditional full recovery. The changes of Lac, Hct, INR, plasma TNF-α and IL-6 levels in two groups were observed before and after the treatment, and the incidence of complications and mortality between the two groups were compared. Results After the treatment, the input of recovery fluid, the MAP and INR in the control group were significant higher than those in the observation group, the difference was statistically significant(P<0.05). The level of Lac in the observation group was declined much more significantly than the control group, which had statistical significance(P<0.05). Hct were significantly decreased in both groups after the treatment, and the control group decreased much more, the differences were statistically significant(P<0.05). The plasma levels of TNF-α and IL-6 in the two groups were significantly increased, and the levels of plasma TNF-α and IL-6 in the observation group were significantly lower than those in the control group after the treatment, the difference was statistically significant(P<0.05). The incidences of MODS, ARDS and the mortality in the observation group were 18.3%, 25.0% and 6.7%, respectively, significantly lower than those in the control group(40.0%, 40.0% and 41.7%, respectively), the difference was statistical significant(P<0.05). Conclusion Limited fluid resuscitation can effectively improve the coagulation function of hemorrhagic shock, inhibit the inflammatory reaction, thereby reducing the incidence of complications, and improve the prognosis of patients.