Abstract: Objective To understand the condition of low back pain and analyze the influencing factors related to low back pain among nurses in intensive care unit (ICU),so as to supply evidence for reducing and preventing occupational injuries. Methods This was a cross-sectional study. From June, 2015 to August, 2015, we investigated 202 ICU nurses from 4 hospitals in Zhejiang province, which were selected by convenience sampling method. General social demographic characteristics, condition of low back pain and the relevant influencing factors of low back pain were investigated. The mean±standard deviation, composition ratio and rate were used to describe the condition of low back pain. Multivariate unconditional logistic regression analyses were used to explore the relevant influencing factors of low back pain. Results The 143 of 202 participants had a vocational low back pain. The prevalence of occupational low back pain among ICU nurses was 70.8%. Among ICU nurses who had lower back pain, in the past year, 40.1% of them had a total duration of illness more than 30 days, 19.3% of them reduced daily activities time for more than 30 days, and 21.8% of them had received examination and treatment. The main factors, which were related to occupational low back pain among ICU nurses were working years (OR=2.17, 95% CI:1.38-3.66), times of lifting heavy loads(OR=2.14, 95% CI:1.18-4.35), occupational stress (OR=1.83, 95% CI:1.24-2.99), physical exercise (OR=0.62, 95% CI:0.41-0.86) and moonlit night shift (OR=2.37, 95% CI:1.53-3.72). Conclusion The condition of low back pain among ICU nurses was serious. Interventions related to influencing factors, such as strengthening the training to correct bad posture, strengthening physical exercise and making scientific work scheduling, should be taken to reduce the incidence of low back pain.