Abstract: Objective To investigate the clinical efficacy of post auricular injection of methylprednisolone on treatment of idiopathic deafness and its effects on hemorheology and plasma Hcy. Methods A total of 106 patients with idiopathic deafness in our hospital from February, 2016 to February, 2017 were randomly divided into two groups according to random number method, 53 cases in every group. The control group was given dexamethasone, and observation group was added post auricular injection of methylprednisolone based on control group. After treatment, the pure tone threshold, hemorheology (plasma viscosity, hematocrit, platelet aggregation rate), plasma Hcy level, clinical efficacy of two groups were compared. Results Before treatment, there was no significant difference on pure tone threshold between the two groups (P>0.05). After treatment, the pure tone threshold of two groups were significantly decreased (P<0.05), and pure tone threshold of observation group was lower than that of control group (P<0.05). Before treatment, there was no significant difference on plasma viscosity, hematocrit, platelet aggregation rate between the two groups (P>0.05). After treatment, the plasma viscosity, hematocrit, platelet aggregation rate of two groups were significantly decreased (P <0.05), and plasma viscosity, hematocrit, platelet aggregation rate of observation group were lower than those of control group (P<0.05). Before treatment, there was no significant difference on Hcy level between the two groups (P>0.05).After treatment, the Hcy level of two groups were significantly decreased (P<0.05), and Hcy level of observation group were lower than that of control group (P<0.05). The total effective rate of observation group was 96.23%, which was significantly higher than that of control group (81.13%), P<0.05. Conclusion The post auricular injection of methylprednisolone on treatment of idiopathic deafness could improve the hemorheology and plasma Hcy level of the patients, is very worth for clinical recommendation.