再生障碍性贫血演变为急性髓系白血病1例并文献复习

高铭敏; 吴涛; 刘文慧; 王向丽; 刘洋; 张睿

doi:10.16766/j.cnki.issn.1674-4152.004517

再生障碍性贫血演变为急性髓系白血病1例并文献复习

doi: 10.16766/j.cnki.issn.1674-4152.004517

高铭敏^{1, 2},
吴涛^2, ,,
刘文慧²,
王向丽²,
刘洋²,
张睿²

1.
甘肃中医药大学第一临床医学院，甘肃兰州 730000
2.
中国人民解放军联勤保障部队第九四〇医院（原兰州军区总医院）全军血液病中心，甘肃兰州 730050

基金项目:

甘肃省创新基地和人才计划项目 21JR7RA015

甘肃省重点研发计划项目 22YF7FA106

联勤保障部队第九四〇医院血液病医学研究中心项目 2021yxky078

甘肃省科技计划项目 25JRRA1184

详细信息

通讯作者:
吴涛，E-mail：wutaozhen@yeah.net

中图分类号: R556.5 R733.71
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- 文章访问数: 10
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出版历程
- 收稿日期: 2025-04-22
- 网络出版日期: 2026-10-23

Aplastic anemia evolving into acute myeloid leukemia: a case report and literature review

GAO Mingmin^{1, 2},
WU Tao^{2
, ,},
LIU Wenhui²,
WANG Xiangli²,
LIU Yang²,
ZHANG Rui²

1.
Gansu University of Chinese Medicine, First School of Clinical Medicine, Lanzhou, Gansu 730000, China

摘要

摘要: 通过回顾性分析1例再生障碍性贫血（AA）后期转为急性髓系白血病（AML）儿童患者的临床资料，分析其临床特征、治疗过程和转归。该患儿诊断为AA后给予环孢素联合雄激素，升白细胞、输注成分血及抗胸腺细胞免疫球蛋白（ATG）联合间充质干细胞等综合治疗后疗效不佳。于2018年AA转为AML，并完善相关检查后进行化疗，总体疗效不佳，2021年患者家属选择外院行嵌合抗原受体T细胞免疫疗法（CAR-T）治疗，后续随访患者因病情恶化加重，抢救无效死亡。进一步学习AA患者转变为AML的临床特点。从而得出对于良性血液疾病并染色体异常的患者经免疫抑制治疗后继发恶性血液肿瘤的概率较高，尽早排除相关染色体核型异常及正常造血细胞恢复不良是尽早避免和降低良性疾病向恶性血液肿瘤转变的关键。
- 再生障碍性贫血 /
- 急性髓系白血病 /
- 克隆性造血 /
- 免疫抑制剂
Abstract: By retrospectively analyzing the clinical data of a pediatric patient with aplastic anemia (AA) converted to acute myeloid leukemia (AML) at a later stage of the disease, we analyzed the clinical characteristics, treatment course, and regression. The child was diagnosed with AA and was given cyclosporine combined with androgens, leukocyte boosting, transfusion of component blood and antithymocyte globulin(ATG) combined with mesenchymal stem cells, and other comprehensive treatments were ineffective. In 2018, AA was converted to AML, and chemotherapy was administered after completing relevant investigations, with poor overall efficacy, and the patient's family chose to undergo chimeric antigen receptor T-cell cellular immunotherapy (CAR-T) treatment at an outside hospital in 2021, and the patient died on subsequent follow-up due to deterioration and aggravation of the condition. Further study of the clinical features of AA patients transformed to AML. Thus, for patients with benign hematologic diseases and chromosomal abnormalities have a higher probability of secondary malignant hematologic tumors after immunosuppressive therapy, and early exclusion of related chromosomal karyotype abnormalities and poor recovery of normal hematopoietic cells is the key to avoid and reduce the transformation of benign diseases to malignant hematologic tumors as early as possible.
- Aplastic anemia /
- Acute myeloid leukemia /
- Clonal hematopoiesis /
- Immunosuppression

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参考文献(23)

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再生障碍性贫血演变为急性髓系白血病1例并文献复习

doi: 10.16766/j.cnki.issn.1674-4152.004517

通讯作者:
吴涛，E-mail：wutaozhen@yeah.net

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Aplastic anemia evolving into acute myeloid leukemia: a case report and literature review

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再生障碍性贫血演变为急性髓系白血病1例并文献复习

doi: 10.16766/j.cnki.issn.1674-4152.004517

通讯作者: 吴涛，E-mail：wutaozhen@yeah.net

计量

出版历程

Aplastic anemia evolving into acute myeloid leukemia: a case report and literature review

计量

出版历程

目录

通讯作者:
吴涛，E-mail：wutaozhen@yeah.net