Clinical research on the treatment of insomnia accompanied by myocardial bridge with Ningxin Kangqiao Sleeping Formula and acupoint application therapy
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摘要:
目的 观察心肌桥伴失眠患者服用宁心康桥安眠方联合穴位贴敷疗法治疗的效果, 为该病的治疗提供新途径。 方法 选取2022年11月-2023年11月在山东中医药大学第二附属医院就诊的90例心肌桥伴失眠患者, 采用随机数字表法分为常规组30例、中药组30例、药穴组30例。常规组给予心肌桥一般西药治疗, 同时给予阿普唑仑片治疗失眠, 中药组在常规组治疗的基础上联合宁心康桥安眠方, 药穴组在中药组的基础上同时加以涌泉穴贴敷疗法。比较各组中医证候积分及匹兹堡睡眠质量指数量表(PSQI)评分变化情况, 评估临床疗效及安全性。 结果 治疗前3组中医证候总积分、PSQI评分比较差异均无统计学意义(P>0.05);治疗后常规组、中药组、药穴组中医证候总积分[(12.26±2.27)分、(7.70±2.37)分、(5.55±2.28)分]、PSQI评分[(12.43±2.08)分、(11.17±2.28)分、(9.33±1.45)分]比较差异均有统计学意义(P < 0.001);治疗后3组匹兹堡睡眠指数及中医证候总积分均明显改善, 差异有统计学意义(P < 0.05)。中药组中医证候总积分、PSQI评分均优于常规组, 药穴组各指标均优于中药组、常规组。 结论 宁心康桥安眠方加减联合穴位贴敷疗法治疗气阴两虚、瘀郁扰神型心肌桥伴失眠患者, 在改善中医症状及睡眠方面效果较佳, 具有较好的临床安全性。 Abstract:Objective To observe the efficacy of Ningxin Kangqiao Sleeping Formula combined with acupoint application therapy in patients with myocardial bridge and insomnia, and to provide a new way for the treatment of this disease. Methods A total of 90 patients with myocardial bridge and insomnia selected from the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine from November 2022 to November 2023 were used the random number table method divided into the conventional group (30 cases), traditional Chinese medicine (TCM) group (30 cases), and medicine acupoint group (30 cases).The conventional group was given general Western medicine treatment for myocardial bridge, and alprazolam tablets were administered for insomnia.The Chinese medicine group was treated with the Ningxin Kangqiao Sleeping Formula in addition to the treatment of the conventional group.The medicine acupoint group was treated with the application of the Yongquan acupoint in addition to the treatment of the Chinese medicine group.The changes of TCM syndrome scores and Pittsburgh sleep quality index were compared to verify their clinical efficacy and evaluate their safety. Results Before treatment, there was no statistically significant difference in the total TCM syndrome score and PSQI score among the three groups (P>0.05).After treatment, the total TCM syndrome scores[(12.26±2.27) points, (7.70±2.37) points, (5.55±2.28) points]and PSQI scores[(12.43±2.08) points, (11.17±2.28) points, (9.33±1.45) points]of the three groups were significantly different (P < 0.001).After treatment, the PSQI and total TCM syndrome scores of the three groups were significantly improved, and the differences were statistically significant (P < 0.05).The total TCM syndrome score and PSQI score of the TCM group were better than those of the conventional group, and the scores of the medicine acupoint group were better than those of the TCM group and the conventional group. Conclusion The addition and subtraction of Ningxin Kangqiao Sleeping Formula combined with acupoint application therapy in the treatment of patients with Qi and Yin deficiency, stasis and disturbance myocardial bridge with insomnia has a better effect in improving TCM symptoms and sleep, and has a good clinical safety. -
Key words:
- Ningxin Kangqiao Sleeping Formula /
- Acupoint application /
- Myocardial bridge /
- Insomnia
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表 1 3组心肌桥伴失眠患者治疗前后中医证候总积分比较(x ±s, 分)
Table 1. Comparison of the total score of traditional Chinese medicine syndromes before and after treatment in patients with myocardial bridge and insomnia(x ±s, points)
组别 例数 治疗前 治疗后 t值 P值 常规组 30 18.07±1.11 12.26±2.27 14.521 ＜0.001 中药组 30 18.23±2.22 7.70±2.37a 18.075 ＜0.001 药穴组 30 18.69±1.20 5.55±2.28ab 30.421 ＜0.001 F值 1.139 66.945 P值 0.325 ＜0.001 注：与常规组比较，aP < 0.05；与中药组比较，bP < 0.05。 
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表 2 3组心肌桥伴失眠患者治疗前后PSQI评分比较(x ±s, 分)
Table 2. Comparison of PSQI scores before and after treatment in 3 groups of patients with myocardial bridge and insomnia(x ±s, points)
组别 例数 治疗前 治疗后 t值 P值 常规组 30 16.53±2.08 12.43±2.08 18.956 ＜0.001 中药组 30 17.50±2.05 11.17±2.28a 21.062 ＜0.001 药穴组 30 17.17±1.66 9.33±1.45ab 29.304 ＜0.001 F值 1.924 50.816 P值 0.152 ＜0.001 注：与常规组比较，aP < 0.05；与中药组比较，bP < 0.05。
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