意义导向疗法对抑郁情绪干预效果的meta分析

贾婷瑞; 王诗琪; 刘取芝

doi:10.16766/j.cnki.issn.1674-4152.004432

意义导向疗法对抑郁情绪干预效果的meta分析

doi: 10.16766/j.cnki.issn.1674-4152.004432

1.
河海大学公共管理学院教育与心理研究所, 江苏南京 210098
2.
河海大学心理健康教育与研究中心, 江苏南京 210098

基金项目:

江苏省教育科学规划重点课题 B/2023/01/196

详细信息

通讯作者:
刘取芝，E-mail：6812930@qq.com

中图分类号: R395.6 R749.79
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- 文章访问数: 15
- HTML全文浏览量: 7
- PDF下载量: 1
- 被引次数: 0
出版历程
- 收稿日期: 2025-07-08
- 网络出版日期: 2026-06-02

Meta-analysis of the intervention effect of meaning-oriented therapy on depressive mood

1.
Institute of Education and Psychology, School of Public Administration, Hohai University, Nanjing, Jiangsu 210098, China

摘要

摘要: 目的本研究旨在通过meta分析系统评估意义导向疗法干预抑郁情绪的总体效果，进一步探讨影响干预效果的潜在调节因素，为心理干预实践提供循证依据。方法系统检索中国知网、万方数据库、中国生物医学文献数据库、Web of Science、PubMed、Cochrane Library、Embase数据库中关于意义导向疗法干预抑郁情绪的随机对照试验研究，检索时间为建库至2024年5月。使用CMA v3.3软件进行效应量合并计算以及调节效应分析。结果研究共纳入26篇随机对照试验研究，总样本量为2 105，年龄为11.00~67.75岁。Meta分析结果显示，合并总效应量SMD=-0.869(95% CI：-1.017~-0.722，P＜0.001)；调节效应分析表明，在meta回归分析中，干预效果受到受试者女性比例、脱落率2个变量的影响(P＜0.05)；亚组分析结果表明，疗法类型、文献质量以及研究地区均对干预效果的调节作用显著(P＜0.05)，测量工具的调节作用不显著。结论意义导向疗法对抑郁情绪具有显著的干预效果。未来的研究可以在中国背景下制定更加本土化、系统化的意义导向疗法干预方案，并系统探索意义导向疗法的实践性和有效性。
- 意义疗法 /
- 意义中心疗法 /
- 意义建构干预 /
- 意义导向疗法 /
- 抑郁 /
- Meta分析
Abstract: Objective To systematically evaluate the overall effectiveness of meaning-oriented therapy in alleviating depressive moods through a meta-analysis, and to further explore potential moderators influencing the intervention outcomes, thereby providing evidence-based support for psychological intervention practices. Methods A comprehensive search was conducted in China National Knowledge Infrastructure, Wanfang Data, China Biology Medicine, Web of Science, PubMed, Cochrane Library, and Embase for RCTs involving meaning-oriented therapy for depressive mood. The search covered all publications up to May 2024. The CMA V3.3 software was used to calculate pooled effect sizes and conduct moderator analyses. Results A total of 26 RCTs were included, with a combined sample size of 2, 105 participants and the age range of 11.00 to 67.75 years. The meta-analysis showed a significant overall effect size (SMD=-0.869, 95% CI: -1.017 to -0.722, P < 0.05). Moderator analyses indicated that, in the meta-regression, the intervention effects were significantly influenced by the proportion of female participants and dropout rate (P < 0.05). Subgroup analyses further revealed that therapy type, study quality, and geographic region had significant moderating effects on the intervention outcomes (P < 0.05), whereas the moderating effect of the depression assessment tool was not significant. Conclusion Meaning-oriented therapy has a significant effect in reducing depressive mood. Future research should focus on developing more localized and systematic meaning-oriented therapy protocols within the Chinese context and further examining their practical application and efficacy.
- Logotherapy /
- Meaning-centered therapy /
- Meaning-making intervention /
- Meaning-oriented therapy /
- Depression /
- Meta-analysis

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图 1 文献筛选流程图

Figure 1. Flowchart of literature selection process

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表 1 纳入文献基本特征

Table 1. Basic characteristics of included studies

第一作者及年份	地区	总样本量	平均年龄(岁)	研究对象	干预措施	测量工具	文献质量
董翠珍, 2022^[12]	中国	102	47.60	慢性肾炎患者	Logotherapy	SDS	B
封蕾, 2017^[13]	中国	156	55.10	血液透析患者	Logotherapy	SDS	B
胡如婷, 2021^[14]	中国	20	-	大学生	Logotherapy	CES-D	C
李岚, 2021^[15]	中国	112	47.70	晚期肝癌患者	MCP	HADS	B
刘明娟, 2009^[16]	中国	60	-	初中生	Logotherapy	SDS	B
陆滢滢, 2023^[17]	中国	60	63.29	癌症患者	Logotherapy	SCL-90	B
明星, 2013^[18]	中国	38	52.06	晚期癌症患者	MMI	HADS	C
周丽娟, 2021^[19]	中国	65	53.27	晚期肺癌患者	MCGP	HADS	C
ALIPOUR F, 2023^[20]	伊朗	32	-	护士	Logotherapy	HADS	C
AREFPOUR A M, 2022^[21]	伊朗	30	-	前列腺癌症	Logotherapy	BDI	B
BREITBART W, 2012^[22]	美国	120	54.40	晚期癌症患者	IMCP	HADS	C
BREITBART W, 2015^[23]	美国	172	57.00	晚期癌症患者	MCGP	BDI	C
BREITBART W, 2018^[24]	美国	168	58.00	晚期癌症患者	IMCP	HADS	B
KIM C, 2020^[25]	韩国	44	77.00	老年人	Logotherapy	GDS-15	C
CHENG M, 2015^[26]	中国	66	22.15	大学生	Logotherapy	GHQ-20	B
FRAGUELL-HERNANDO C, 2020^[27]	西班牙	32	67.75	晚期癌症患者	IMCP	HADS	C
SUN F K, 2022^[28]	中国	86	53.30	抑郁症患者	Logotherapy	BDI	B
DA PONTE G, 2021^[29]	葡萄牙	91	61.04	癌症患者	MCGP	HADS	C
HENRY M, 2010^[30]	加拿大	24	-	卵巢癌患者	MMI	HADS	A
KANG K A, 2013^[31]	韩国	142	11.00	学生	Logotherapy	CDI	C
LEE S, 2019^[32]	韩国	47	-	大学生	Logotherapy	BDI	B
RAJI LAHIJI M, 2022^[33]	伊朗	90	50.40	乳腺癌患者	Logotherapy	BDI	B
SHAYGAN M, 2023^[34]	伊朗	70	34.27	单相抑郁症	Logotherapy	BDI	B
VAN DER SPEK N, 2017^[35]	荷兰	114	58.60	癌症患者	MCGP	HADS	A
VAN DOORNIK S F W, 2024^[36]	荷兰	124	19.72	饮食失调患者	MCP	DASS-21	B
CHO S, 2008^[37]	韩国	40	44.37	酗酒者妻子	Logotherapy	SCL-90	C
注：抑郁自评量表为SDS(self-rating depression scale)；流调中心抑郁量表为CES-D(center for epidemiologic studies depression scale)；心理健康临床症状自评量表为SCL-90(symptom checklist-90)；医院焦虑抑郁评价量表为HADS(hospital anxiety and depression scale)；贝克抑郁量表为BDI(Beck depression inventory)；一般健康问卷为GHQ-20(general health questionnaire-20)；15项老年抑郁量表为GDS-15(geriatric depression scale-15)；抑郁-焦虑-压力量表为DASS-21(depression anxiety and stress scale)；儿童抑郁量表为CDI(children' s depression inventory); logotherapy，意义疗法；individual meaning-centered psychotherapy(IMCP)，个体意义中心疗法；meaning-centered group psychotherapy(MCGP)，团体意义中心疗法；meaning-centered psychotherapy(MCP)，意义中心疗法；意义建构干预为MMI(meaning making intervention)。“-”表示该研究并未报告此内容。

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表 2 意义导向疗法干预抑郁情绪的meta回归分析

Table 2. Meta-regression analysis of meaning-oriented therapy for depressive mood

调节变量	B	SE	P值	调节分析
调节变量	B	SE	P值	Q	P值	R²
女性占比	0.709	0.313	0.023	5.140	0.023	0.250
脱落率	1.574	0.574	0.006	7.520	0.006	0.420
注：Q代表研究间差异；R²代表异质性比例。

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表 3 意义导向疗法干预抑郁情绪的亚组分析

Table 3. Subgroup analysis of meaning-oriented therapy for depressive mood

调节变量		K	SMD	95% CI	Q_b	P值
国家地域	东方	18	-1.047	-1.166~-0.928	19.351	< 0.001
	西方	8	-0.543	-0.734~-0.353
质量评价	A	2	-0.331	-0.667~0.005	10.272	0.006
	B	13	-0.973	-1.176~-0.769
	C	11	-0.814	-1.021~-0.606
干预措施	Logotherapy	15	-1.064	-1.194~-0.934	13.732	0.001
	MCP	9	-0.675	-0.896~-0.454
	MMI	2	-0.383	-0.886~0.120
测量工具	SDS	3	-1.095	-1.424~-0.767	3.772	0.152
	HADS	10	-0.695	-0.931~-0.458
	BDI	6	-0.846	-1.176~-0.516
注: K代表研究的数目；SMD代表分类变量的效应量；Q_b表示组间异质性。

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