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社区家庭医生签约的老年2型糖尿病患者合并慢性便秘现况及临床特征分析

朱雪梅 陶洁 谭娟

朱雪梅, 陶洁, 谭娟. 社区家庭医生签约的老年2型糖尿病患者合并慢性便秘现况及临床特征分析[J]. 中华全科医学, 2026, 24(3): 460-463. doi: 10.16766/j.cnki.issn.1674-4152.004419
引用本文: 朱雪梅, 陶洁, 谭娟. 社区家庭医生签约的老年2型糖尿病患者合并慢性便秘现况及临床特征分析[J]. 中华全科医学, 2026, 24(3): 460-463. doi: 10.16766/j.cnki.issn.1674-4152.004419
ZHU Xuemei, TAO Jie, TAN Juan. Prevalence and clinical characteristics of chronic constipation in elderly patients with type 2 diabetes mellitus under family doctor contract management[J]. Chinese Journal of General Practice, 2026, 24(3): 460-463. doi: 10.16766/j.cnki.issn.1674-4152.004419
Citation: ZHU Xuemei, TAO Jie, TAN Juan. Prevalence and clinical characteristics of chronic constipation in elderly patients with type 2 diabetes mellitus under family doctor contract management[J]. Chinese Journal of General Practice, 2026, 24(3): 460-463. doi: 10.16766/j.cnki.issn.1674-4152.004419

社区家庭医生签约的老年2型糖尿病患者合并慢性便秘现况及临床特征分析

doi: 10.16766/j.cnki.issn.1674-4152.004419
基金项目: 

江苏省干部保健科研面上项目 BJ24045

江苏省老年健康科研面上项目 LKM2022069

详细信息
    通讯作者:

    谭娟,E-mail:hayytan664@sina.com

  • 中图分类号: R587.1 R442.2

Prevalence and clinical characteristics of chronic constipation in elderly patients with type 2 diabetes mellitus under family doctor contract management

  • 摘要:   目的  了解社区签约老年2型糖尿病(type 2 diabetes mellitus, T2DM)患者慢性便秘的患病现况,深入分析其在代谢指标、生活方式及心理状态等方面的临床特征,旨在为社区老年糖尿病患者的综合干预提供科学依据。  方法  选取2022年6月—2024年6月于淮安市淮海社区签约的293例老年T2DM患者进行横断面调查。采集患者人口学特征、生活方式、便秘症状、心理评分及生化指标,比较便秘组与非便秘组差异。  结果  慢性便秘患病率为37.5%(110/293)。与非便秘组相比,便秘组年龄更大[(74.26±7.69)岁vs.(70.66±6.25)岁,P < 0.001]及糖尿病病程更长[15.00(5.00, 20.00)年vs. 10.00(5.00, 18.50)年,P=0.016];粗粮摄入(47.71% vs. 61.67%,P=0.020)、每日饮水(72.22% vs. 84.83%, P=0.010)、睡眠时长(38.89% vs. 52.51%, P=0.025)及运动量(72.48% vs. 83.71%, P=0.022)达标率均降低。此外,便秘组糖化血红蛋白水平更高[(7.82±1.70)% vs.(7.24±1.08)%, P=0.019]、焦虑抑郁评分更高(P < 0.001),而估算肾小球滤过率更低[(79.97±21.81)mL/(min·1.73 m2) vs.(86.69±24.99)mL/(min·1.73 m2),P=0.023]。  结论  社区老年T2DM合并便秘患者具有高龄、长病程、血糖控制欠佳、肾功能相对减退、焦虑抑郁严重及生活方式不良的临床特征。

     

  • 表  1  2组2型糖尿病患者临床资料比较

    Table  1.   Comparison of baseline characteristics between the two groups of patients with type 2 diabetes mellitus

    项目 非便秘组(n=183) 便秘组(n=110) 统计量 P
    年龄(x±s, 岁) 70.66±6.25 74.26±7.69 -4.164a < 0.001
    体重指数(x±s) 25.34±3.20 24.77±2.90 1.512a 0.132
    糖尿病病程[M(P25, P75), 年] 10.00 (5.00, 18.50) 15.00 (5.00, 20.00) -2.402b 0.016
    腰围(x±s, cm) 88.54±9.00 89.42±9.00 -0.765a 0.445
    糖尿病药物使用[例(%)] 0.007c 0.934
      否 16(8.90) 10(9.17)
      是 164(91.10) 99(90.83)
    拜糖平[例(%)] 0.016c 0.901
      否 141(77.90) 85(77.27)
      是 40(22.10) 25(22.73)
    二甲双胍[例(%)] 0.043c 0.835
      否 76(41.99) 44(40.74)
      是 105(58.01) 64(59.26)
    教育情况[例(%)] 1.408c 0.495
      小学及以下 25(14.97) 21(19.81)
      中学和高中 78(46.71) 50(47.17)
      大专及以上 64(38.32) 35(33.02)
    性别[例(%)] 1.670c 0.196
      男性 99(54.10) 68(61.82)
      女性 84(45.90) 42(38.18)
    高血压[例(%)] 3.364c 0.067
      否 51(27.87) 20(18.35)
      是 132(72.13) 89(81.65)
    注:at值,bZ值,c为χ2值。
    下载: 导出CSV

    表  2  2组2型糖尿病患者生活方式比较[例(%)]

    Table  2.   Comparison of lifestyle between patients with type 2 diabetes [n (%)]

    项目 非便秘组(n=183) 便秘组(n=110) χ2 P
    水果摄入充足 0.119 0.731
      否 56 (31.28) 32 (29.36)
      是 123 (68.72) 77 (70.64)
    蔬菜摄入充足 0.196 0.658
      否 97 (54.49) 57 (51.82)
      是 81 (45.51) 53 (48.18)
    粗粮摄入充足 5.381 0.020
      否 69 (38.33) 57 (52.29)
      是 111 (61.67) 52 (47.71)
    饮水充足 6.697 0.010
      否 27 (15.17) 30 (27.78)
      是 151(84.83) 78(72.22)
    运动充足 5.221 0.022
      否 29(16.29) 30(27.52)
      是 149(83.71) 79(72.48)
    饮酒 0.000 0.991
      否 121(67.22) 72(67.29)
      是 59(32.78) 35(32.71)
    吸烟 0.184 0.668
      否 141(77.90) 81(75.70)
      是 40(22.10) 26(24.30)
    睡眠充足 5.016 0.025
      否 85(47.49) 66(61.11)
      是 94(52.51) 42(38.89)
    下载: 导出CSV

    表  3  2型糖尿病合并慢性便秘及未合并便秘患者的精神心理评估状态比较

    Table  3.   Comparison of psychological assessment results between patients with type 2 diabetes mellitus complicated by chronic constipation and those without constipation

    组别 例数 SAS(x±s, 分) GDS15 [M(P25, P75), 分]
    非便秘组 183 36.11±6.26 1.00 (1.00, 2.00)
    便秘组 110 42.69±8.50 2.00 (1.00, 4.25)
    统计量 -6.971a -5.336b
    P < 0.001 < 0.001
    注:at值,bZ值。
    下载: 导出CSV

    表  4  2型糖尿病合并慢性便秘与未合并便秘患者血生化指标比较

    Table  4.   Comparison of blood biochemical indicators between patients with type 2 diabetes complicated by chronic constipation and those without constipation

    组别 例数 糖化血红蛋白(x±s,%) 空腹C肽[M(P25, P75), pmol/L] 总胆固醇(x±s,mmol/L) 甘油三酯[M(P25, P75), mmol/L] HDL-C (x±s,mmol/L) LDL-C (x±s,mmol/L) 尿酸(x±s,μmol/L) eGFR[x±s,mL/(min·1.73m2)] 血钙(x±s, mmol/L) 血钾(x±s, mmol/L)
    非便秘组 183 7.24±1.08 740.50(534.50, 969.25) 4.54±1.29 1.27 (0.97, 2.03) 1.31±0.38 2.50±0.90 308.01±91.52 86.69±24.99 2.35±0.16 4.05±0.40
    便秘组 110 7.82±1.70 712.00(577.50, 968.50) 4.36±1.42 1.24 (0.91, 1.92) 1.25±0.32 2.37±1.00 316.98±106.52 79.97±21.81 2.34±0.16 4.02±0.36
    统计量 -2.385a -0.112b 1.081a 0.694b 1.420a 1.139a 0.557a 2.289a 0.241a 0.336a
    P 0.019 0.911 0.281 0.488 0.157 0.256 0.578 0.023 0.810 0.737
    注:at值,bZ值。
    下载: 导出CSV
  • [1] 中国老年2型糖尿病防治临床指南编写组, 中国老年医学学会老年内分泌代谢分会, 中国老年保健医学研究会老年内分泌与代谢分会, 等. 中国老年2型糖尿病防治临床指南(2022年版)[J]. 中华内科杂志, 2022, 61(1): 12-50.

    Chinese Elderly Type 2 Diabetes Prevention and Treatment of Clinical Guidelines Writing Group, Geriatric Endocrinology and Metabolism Branch of Chinese Geriatric Society, Geriatric Endocrinology and Metabolism Branch of Chinese Geriatric Health Care Society, et al. Clinical guidelines for prevention and treatment of type 2 diabetes mellitus in the elderly in China (2022 edition)[J]. Chinese Journal of Internal Medicine, 2022, 61(1): 12-50.
    [2] YAN Y Q, WU T T, ZHANG M, et al. Prevalence, awareness and control of type 2 diabetes mellitus and risk factors in Chinese elderly population[J]. BMC Public Health, 2022, 22(1): 1382. DOI: 10.1186/s12889-022-13759-9.
    [3] DEB B, PRICHARD D O, BHARUCHA A E. Constipation and fecal incontinence in the elderly[J]. Curr Gastroenterol Rep, 2020, 22(11): 54. DOI: 10.1007/s11894-020-00791-1.
    [4] ZHANG T, ZULLO A R, JAMES H O, et al. The burden and treatment of chronic constipation among US nursing home residents[J]. J Am Med Dir Assoc, 2023, 24(8): 1247-1252.e1245. DOI: 10.1016/j.jamda.2023.05.006.
    [5] MOGESS W N, MIHRETIE T B, HABTE M L, et al. The magnitude of chronic constipation and associated factors among type 2 diabetic patients in Harar, Eastern Ethiopia[J]. Clin Diabetes Endocrinol, 2024, 10(1): 33. DOI: 10.1186/s40842-024-00188-3.
    [6] ABDU SEID M, DIRESS M, MOHAMMED A, et al. Chronic constipation and its associated factors in patients with type-2 diabetes: a multicenter cross-sectional study[J]. Diabetes Res Clin Pract, 2023, 204: 110905. DOI: 10.1016/j.diabres.2023.110905.
    [7] World Health Organization. Classification of diabetes mellitus, 2019[M]. Geneva: WHO Document Production Services, 2019.
    [8] DROSSMAN D A, HASLER W L. Rome Ⅳ-functional GI disorders: disorders of gut-brain interaction[J]. Gastroenterology, 2016, 150(6): 1257-1261. doi: 10.1053/j.gastro.2016.03.035
    [9] GONG B Y, MA H M, ZANG X Y, et al. Efficacy of cranial electrotherapy stimulation combined with biofeedback therapy in patients with functional constipation[J]. J Neurogastroenterol Motil, 2016, 22(3): 497-508. doi: 10.5056/jnm15089
    [10] 唐丹. 简版老年抑郁量表(GDS-15)在中国老年人中的使用[J]. 中国临床心理学杂志, 2013, 21(3): 402-405.

    TANG D. Application of short form geriatric depression scale (GDS-15) in Chinese elderly[J]. Chinese Journal of Clinical Psycholog, 2013, 21(3): 402-405.
    [11] YURTDA?瘙塁G, ACAR-TEK N, AKBULUT G, et al. Risk factors for constipation in adults: a cross-sectional study[J]. J Am Coll Nutr, 2020, 39(8): 713-719. doi: 10.1080/07315724.2020.1727380
    [12] BHARUCHA A E, LACY B E. Mechanisms, evaluation, and management of chronic constipation[J]. Gastroenterology, 2020, 158(5): 1232-1249.e1233. DOI: 10.1053/j.gastro.2019.12.034.
    [13] MELDGAARD T, KELLER J, OLESEN A E, et al. Pathophysiology and management of diabetic gastroenteropathy[J]. Therap Adv Gastroenterol, 2019, 12: 1756284819852047. DOI: 10.1177/1756284819852047.
    [14] KORNUM D S, BERTOLI D, KUFAISHI H, et al. Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial[J]. Diabetologia, 2024, 67(6): 1122-1137. doi: 10.1007/s00125-024-06129-0
    [15] MARTIN F P, COMINETTI O, BERGER B, et al. Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic[J]. Gut Microbes, 2024, 16(1): 2347715. DOI: 10.1080/19490976.2024.2347715.
    [16] BALLOU S, KATON J, SINGH P, et al. Chronic diarrhea and constipation are more common in depressed individuals[J]Clin Gastroenterol Hepatol, 2019, 17(13): 2696-2703. doi: 10.1016/j.cgh.2019.03.046
    [17] 俞汀, 朱锋, 林琳, 等. 合并上消化道症状对功能性便秘患者焦虑、抑郁及生活质量的影响[J]. 中华全科医学, 2022, 20(10): 1641-1644. doi: 10.16766/j.cnki.issn.1674-4152.002668

    YU T, ZHU F, LIN L, et al. Impact of combined upper gastrointestinal symptoms on anxiety, depression and quality of life of patients with functional constipation[J]. Chinese Journal of General Practice, 2022, 20(10): 1641-1644. doi: 10.16766/j.cnki.issn.1674-4152.002668
    [18] ADIBI P, ABDOLI M, DAGHAGHZADEH H, et al. Relationship between depression and constipation: results from a large cross-sectional study in adults[J]. Korean J Gastroenterol, 2022, 80(2): 77-84. doi: 10.4166/kjg.2022.038
    [19] GIMENES G M, PEREIRA J N B, BORGES DA SILVA E, et al. Intestinal motility dysfunction in Goto-Kakizaki rats: role of the myenteric plexus[J]. Cells, 2024, 13(19): 1626. DOI: 10.3390/cells13191626.
    [20] 刘莉. 基于菌-肠-脑轴的肠肽与焦虑抑郁关系的研究进展[J]. 中华全科医学, 2022, 20(8): 1388-1391, 1399. doi: 10.16766/j.cnki.issn.1674-4152.002604

    LIU L. Research progress of intestinal peptides and the occurrence of anxiety and depression on the basis of the microbiota-gut-brain axis[J]. Chinese Journal of General Practice, 2022, 20(8): 1388-1391, 1399. doi: 10.16766/j.cnki.issn.1674-4152.002604
    [21] WEI L G, JI L Q, MIAO Y L, et al. Constipation in DM are associated with both poor glycemic control and diabetic complications: current status and future directions[J]. Biomed Pharmacother, 2023, 165: 115202. DOI: 10.1016/j.biopha.2023.115202.
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  • 收稿日期:  2025-02-19
  • 网络出版日期:  2026-06-02

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