Study on the curative effect of added Banxia Baizhu Tianma Decoction combined with Meridian craping in the treatment of phlegm-dampness obstructing hypertension
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摘要:
目的 探讨加味半夏白术天麻汤联合循经刮痧治疗痰湿壅盛型高血压的临床疗效及对血液黏度的影响,为高血压的临床治疗提供可靠的中西医结合方案。 方法 选择2024年1—5月河南中医药大学第一附属医院心脏中心收治的104例高血压患者,按照随机数字表法分为对照组(52例)和研究组(52例)。对照组给予氨氯地平治疗,研究组加用加味半夏白术天麻汤联合循经刮痧,6周后比较2组治疗效果、血压变化、中医证候积分、血液黏度以及不良反应的发生情况。 结果 研究组总有效率为90.38%(47/52),高于对照组的73.08%(38/52),χ2=4.300,P=0.038;治疗后2组收缩压、舒张压有所降低,且研究组低于对照组[(126.31±6.28)mmHg vs. (130.48±7.20)mmHg;(75.54±7.12)mmHg vs. (79.85±6.30)mmHg,P < 0.05,1 mmHg=0.133 kPa];治疗后2组中医证候积分、红细胞聚集指数、血浆黏度较治疗前降低(P < 0.05),且研究组低于对照组(P < 0.05)。 结论 联合应用加味半夏白术天麻汤和循经刮痧治疗高血压效果良好,可进一步降低血压,改善中医体质,调节血液黏度,安全性良好。 Abstract:Objective To investigate the clinical efficacy of supplemented Banxia Baizhu Tianma Decoction combined with Meridian craping in treating hypertension with phlegm-dampness obstructing and its influence on blood viscosity, and to provide a reliable integrated plan for the clinical treatment of hypertension. Methods A total of 104 hypertensive patients were admitted to the First Affiliated Hospital of Henan University of Chinese Medicine from January 2024 to May 2024. These patients were divided into a control group and a study group, with 52 patients assigned according to the random number table. The control group received amlodipine treatment, while the study group received a combination of supplemented Banxia Baizhu Tianma Decoction and Meridian scraping. Following a period of six weeks, a comparison was made of the therapeutic effect, blood pressure change, TCM syndrome score, blood viscosity and the occurrence of adverse reactions. Results The total effective rate of the study group was 90.38% (47/52), which was higher than that in the control group [73.08% (38/52), χ2=4.300, P=0.038]. After treatment, SBP and DBP in two groups were lower (P < 0.05), and the study group were lower than control group [(126.31±6.28) mmHg vs. (130.48±7.20) mmHg, (75.54±7.12) mmHg vs. (79.85±6.30) mmHg, P < 0.05, 1 mmHg=0.133 kPa]. After treatment, a reduction in TCM syndrome score, red blood cell aggregation index and plasma viscosity was observed in both groups (P < 0.05), and the study group were lower than control group (P < 0.05). Conclusion Supplemented Banxia Baizhu Tianma Decoction combined with Meridian scraping has a good effect on treating hypertension, which can further reduce blood pressure, improve TCM syndromes, regulate blood viscosity and have good safety. -
表 1 2组高血压患者一般资料比较
Table 1. Comparison of general information between two groups of hypertensive patients
组别 例数 性别(例) 年龄
(x±s,岁)高血压分级[例(%)] 高血压病程
(x±s,年)男性 女性 Ⅰ级 Ⅱ级 研究组 52 27 25 57.64±9.33 24(46.15) 28(53.85) 6.47±1.04 对照组 52 29 23 58.41±8.79 21(40.38) 31(59.62) 6.75±1.21 统计量 0.155a 0.433b 0.353c 1.265b P值 0.694 0.666 0.553 0.209 注:a为χ2值,b为t值,c为Z值。 表 2 2组高血压患者总有效率比较[例(%)]
Table 2. Comparison of total effective rates between two groups of hypertensive patients [case (%)]
组别 例数 显效 有效 无效 总有效 研究组 52 19(36.54) 28(53.85) 5(9.62) 47(90.38) 对照组 52 13(25.00) 25(48.08) 14(26.92) 38(73.08) 注:2组总有效率比较,χ2=4.300,P=0.038。 表 3 2组高血压患者血压比较(x±s,mmHg)
Table 3. Comparison of blood pressure between two groups of hypertensive patients (x±s, mmHg)
组别 例数 SBP DBP 治疗前 治疗后 治疗前 治疗后 研究组 52 161.33±9.52 126.31±6.28b 100.75±5.21 75.54±7.12b 对照组 52 160.74±10.13 130.48±7.20b 101.36±4.88 79.85±6.30b 统计量 0.306a -3.902c -0.616a -4.028c P值 0.760 < 0.001 0.539 < 0.001 注:a为t值,c为F值;与同组治疗前比较,bP < 0.05。 表 4 2组高血压患者中医证候积分比较(x±s,分)
Table 4. Comparison of traditional chinese medicine syndrome points between two groups of hypertensive patients (x±s, points)
组别 例数 眩晕 头痛 头重如裹 胸脘痞闷 呕吐痰涎 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 研究组 52 4.37±0.72 1.58±0.49b 4.42±0.63 1.41±0.35b 4.28±0.80 1.53±0.46b 3.95±0.93 1.63±0.54b 3.75±1.12 1.46±0.43b 对照组 52 4.51±0.65 2.04±0.63b 4.37±0.74 1.98±0.55b 4.36±0.68 2.11±0.57b 4.04±0.87 2.07±0.62b 3.85±0.96 1.92±0.59b 统计量 -1.041a -3.461c 0.371a -6.305c -0.549a -5.710c -0.510a -3.210c -0.244a -4.346c P值 0.300 0.001 0.711 < 0.001 0.584 < 0.001 0.611 0.002 0.807 < 0.001 注:a为t值;c为F值;与同组治疗前比较,bP < 0.05。 表 5 2组高血压患者血液黏度比较(x±s)
Table 5. Comparison of blood viscosity between two groups of hypertensive patients (x±s)
组别 例数 红细胞聚集指数 血浆黏度(mPa·s) 治疗前 治疗后 治疗前 治疗后 研究组 52 2.48±0.71 1.68±0.42b 2.03±0.34 1.44±0.32b 对照组 52 2.53±0.65 1.96±0.55b 1.99±0.40 1.62±0.43b 统计量 -0.375a -3.945c 0.549a -3.810c P值 0.709 0.004 0.584 0.017 注:a为t值;c为F值;与同组治疗前比较,bP < 0.05。 -
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