老年胸椎多发嗜酸性肉芽肿1例

李同观; 张朝伟; 孙广智; 侯岩峰

doi:10.16766/j.cnki.issn.1674-4152.004316

老年胸椎多发嗜酸性肉芽肿1例

doi: 10.16766/j.cnki.issn.1674-4152.004316

李同观^{1, 2},
张朝伟³,
孙广智⁴,
侯岩峰^5, ,

1.
山东第一医科大学研究生部, 山东济南 250014
2.
日照市人民医院风湿免疫科, 山东日照 276800
3.
乐陵市中医院内一科, 山东德州 253600
4.
山东第一医科大学第一附属医院(山东省千佛山医院)骨科, 山东济南 250014
5.
山东第一医科大学第一附属医院(山东省千佛山医院)风湿免疫科山东第一医科大学第一附属医院(山东省千佛山医院)临床免疫转化医学山东省高校实验室

基金项目:

山东省医学会流式细胞术淋巴细胞亚群动态监测临床科研专项资金 YXH2022ZX03223

广州普康基金会资助项目 GZPK2021穗资字Z0629号

中关村精准医学基金会项目 RCTAIIRSLE021

详细信息

通讯作者:
侯岩峰，E-mail: yfhou1016@163.com

中图分类号: R681.7
计量
- 文章访问数: 6
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- PDF下载量: 0
- 被引次数: 0
出版历程
- 收稿日期: 2025-01-13
- 网络出版日期: 2026-03-13

Multiple eosinophilic granuloma of thoracic vertebrae in an elderly patient

1.
Graduate School of Shandong First Medical University, Jinan, Shandong 250014, China

摘要

摘要: 本文报道1例罕见的老年胸椎多发骨嗜酸性肉芽肿(eosinophilic granuloma, EG)病例。患者男性，66岁，因“腰背疼痛伴乏力两年余，加重三个月”就诊。经糖皮质激素联合免疫抑制保守治疗后临床表现及实验室检查好转，病理活检显示肉芽肿组织消失，后因病变部位出现压缩性骨折行外科手术治疗。该病例提示糖皮质激素联合环磷酰胺治疗成人多部位骨嗜酸性肉芽肿患者是可行的。
- 骨嗜酸性肉芽肿 /
- 胸椎 /
- 老年
Abstract: This article reports a rare case of elderly thoracic vertebral multifocal eosinophilic granuloma (EG). The patient, a 66-year-old male, presented with "low back and waist pain accompanied by fatigue for over two years, and worsening for three months." After treatment with glucocorticoids combined with immunosuppressive conservative therapy, the clinical manifestations and laboratory tests improved. Pathological biopsy showed the disappearance of granulomatous tissue. Subsequently, due to the occurrence of compression fractures in the affected area, surgical treatment was carried out. This suggests that the treatment of glucocorticoids combined with cyclophosphamide is feasible for adult patients with multi-site bone eosinophilic granuloma.
- Eosinophilic granuloma of bone /
- Thoracic vertebrae /
- The aged

HTML全文

图 1 老年胸椎多发骨嗜酸性肉芽肿患者胸椎CT平扫矢状面影像

注：白色箭头示T_10~11骨质破坏并椎旁软组织密度增高；A为骨窗矢状重组；B为软组织窗矢状重组。

Figure 1. Coronal CT plain scan images of the thoracic vertebrae in elderly patients with multiple eosinophilic granulomas in the thoracic vertebrae

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图 2 老年胸椎多发骨嗜酸性肉芽肿患者胸椎CT平扫横断面影像

注：A~E分别为胸椎CT骨窗横断面(T_8~12)，F~J分别为胸椎CT软组织窗横断面(T_8~12)T₈、T₁₂为正常锥体，T₉出现锥体边缘不规则，T₁₀、T₁₁骨质破坏并椎旁软组织密度增高。

Figure 2. CT plain-scan cross-sectional images of the thoracic vertebrae in elderly patients with multiple eosinophilic granulomas in the thoracic vertebrae

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图 3 老年胸椎多发骨嗜酸性肉芽肿患者胸椎组织病理结果

注：A示骨髓腔内均为纤维组织增生(HE染色，×10)；B红色箭头示嗜酸性粒细胞浸润灶；蓝色箭头示骨小梁(嗜酸性的基质)；黑色箭头示纤维组织增生(HE染色，×20)；C示嗜酸性粒细胞浸润，可见骨髓腔内有多量嗜酸性粒细胞，其细胞特征为2~3个核叶，胞质浅红色，富含橘红色嗜酸性颗粒(HE染色，×40)；D示纤维组织增生，可见骨髓腔内有大量纤维组织(HE染色，×40)。

Figure 3. Pathological results of thoracic vertebrae tissues in elderly patients with multiple eosinophilic granulomas in the thoracic vertebrae

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