乳清蛋白、ω-3脂肪酸联合抗阻运动对老年肌少症患者功能的影响

王艳; 吴笑雪; 林圆圆; 李建美; 解艳红

doi:10.16766/j.cnki.issn.1674-4152.004292

乳清蛋白、ω-3脂肪酸联合抗阻运动对老年肌少症患者功能的影响

doi: 10.16766/j.cnki.issn.1674-4152.004292

1.
浙江中医药大学附属丽水中医院肾病风湿科，浙江丽水 323000
2.
浙江中医药大学附属丽水中医院老年医学科
3.
浙江医院老年医学科，浙江杭州 330013

基金项目:

浙江省医药卫生科技计划项目 2023KY005

详细信息

通讯作者:
王艳，E-mail：wangyan20230823@163.com

中图分类号: R685
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出版历程
- 收稿日期: 2025-05-29
- 网络出版日期: 2026-03-13

The effect of whey protein and ω-3 fatty acids combined with resistance exercise on the function of elderly sarcopenia patients

1.
Department of Nephrology and Rheumatology, Lishui TCM Hospital Affiliated to Zhejiang Chinese Medical University, Lishui, Zhejiang 323000, China

摘要

摘要: 目的随着全球人口老龄化，肌少症已成为影响老年人健康的重要问题。现有干预主要集中在营养补充和运动训练，但效果有限。本研究探讨乳清蛋白联合ω-3脂肪酸和低强度抗阻运动对老年肌少症患者肌肉质量、力量、步速及日常生活能力的综合改善效果。方法选取2022年6月—2024年6月在浙江中医药大学附属丽水中医院确诊的178例老年肌少症患者，采用随机数字表法分为研究组与对照组，每组各89例。对照组接受常规健康教育与低强度步行，研究组接受乳清蛋白和ω-3脂肪酸补充的同时进行低强度抗阻训练。评估指标包括肌肉质量、肌肉力量、步速、日常生活能力(ADL)及简短肌肉功能测试(SPPB)。结果治疗后研究组患者的肌肉质量[(4.61±0.52)kg/m²]、肌肉力量[(45.82±5.86)kg]均高于对照组[(3.52±0.45)kg/m²、(40.26±4.29)kg]，步速测试[(4.12±0.55)s]低于对照组[(5.67±0.69)s，P＜0.05]；治疗后研究组患者的ADL评分[(92.53±16.46)分]高于对照组[(81.51±11.26)分, P＜0.05]；治疗后研究组患者的SPPB评分[(10.16±1.46)分]高于对照组[(8.26±1.27)分, P＜0.05]。结论乳清蛋白联合ω-3脂肪酸辅以低强度抗阻运动对老年肌少症患者的躯体功能和日常生活能力有显著的积极影响。
- 肌少症 /
- 老年 /
- 乳清蛋白 /
- ω-3脂肪酸 /
- 低强度抗阻运动 /
- 日常生活能力
Abstract: Objective With the global aging population, sarcopenia has become a significant health issue affecting the elderly. Current interventions primarily focus on nutritional supplementation and exercise training, but their effects are limited. This study explores the combined effects of whey protein, ω-3 fatty acids, and low-intensity resistance exercise on muscle mass, strength, walking speed, and daily living ability in elderly sarcopenia patients. Methods A total of 178 elderly patients diagnosed with sarcopenia between June 2022 and June 2024 at the Lishui Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University were selected. They were divided into the study group and control group using a random number table, with 89 cases in each group. The study group received whey protein and ω-3 fatty acid supplementation along with low-intensity resistance training, while the control group received conventional health education and low-intensity walking. Assessment indicators included muscle mass, muscle strength, walking speed, activities of daily living (ADL), and the short physical performance battery (SPPB). Results After treatment, the study group had higher muscle mass [(4.61±0.52) kg/m²] and muscle strength [(45.82±5.86) kg] than the control group [(3.52±0.45) kg/m², (40.26±4.29) kg], and had a shorter walking speed [(4.12±0.55) s] compared to the control group [(5.67±0.69) s, P < 0.05]. The ADL score in the study group [(92.53±16.46) points] was higher than that in the control group [(81.51±11.26) points, t=5.213, P < 0.05]. The SPPB score in the study group [(10.16±1.46) points] was higher than that in the control group [(8.26±1.27) points, t=9.263, P < 0.05]. Conclusion Whey protein combined with ω-3 fatty acids and low-intensity resistance exercise has a significant positive effect on the physical function and activities of daily living in elderly sarcopenia patients.
- Sarcopenia /
- Elderly /
- Whey protein /
- ω-3 fatty acids /
- Low intensity resistance exercise /
- Daily living ability

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表 1 2组老年肌少症患者一般资料比较

Table 1. Comparison of general data between the two groups of elderly sarcopenia patients

组别	例数	性别[例(%)]		年龄(x±s, 岁)	BMI (x±s)
组别	例数	男性	女性	年龄(x±s, 岁)	BMI (x±s)
研究组	89	41(46.07)	48(53.93)	73.35±8.82	22.18±3.07
对照组	89	39(43.82)	50(56.18)	72.63±8.25	21.98±2.92
统计量		0.091^a		0.562^b	0.445^b
P值		0.763		0.575	0.657
注：^a为χ²值，^b为t值。

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表 2 2组老年肌少症患者治疗前后躯体功能比较(x±s)

Table 2. Comparison of physical function between the two groups of elderly patients with sarcopenia before and after treatment (x±s)

组别	例数	肌肉质量(kg/m²)		肌肉力量(kg)		步速测试(s)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
研究组	89	3.12±0.46	4.61±0.52^b	33.61±5.69	45.82±5.86^b	7.09±1.05	4.12±0.55^b
对照组	89	3.11±0.51	3.52±0.45^b	32.95±5.11	40.26±4.29^b	6.92±1.12	5.67±0.69^b
统计量		0.137^a	114.006^c	0.814^a	30.950^c	1.045^a	54.056^c
P值		0.891	＜0.001	0.417	＜0.001	0.298	＜0.001
注：^a为t值，^c为F值；与同组治疗前比较，^bP＜0.05。

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表 3 2组老年肌少症患者治疗前后日常生活能力比较(x±s, 分)

Table 3. Comparison of daily living ability between the two groups of elderly patients with sarcopenia before and after treatment (x±s, points)

组别	例数	ADL评分
组别	例数	治疗前	治疗后
研究组	89	58.47±11.25	92.53±16.46^b
对照组	89	59.02±10.65	81.51±11.26^b
统计量		0.335^a	15.299^c
P值		0.738	＜0.001
注：^a为t值，^c为F值；与同组治疗前比较，^bP＜0.05。

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表 4 2组老年肌少症患者治疗前后生活自理能力比较(x±s, 分)

Table 4. Comparison of self-care ability between the two groups of elderly patients with sarcopenia before and after treatment (x±s, points)

组别	例数	SPPB评分
组别	例数	治疗前	治疗后
研究组	89	6.47±1.03	10.16±1.46^b
对照组	89	6.59±0.92	8.26±1.27^b
统计量		0.820^a	49.893^c
P值		0.413	＜0.001
注：^a为t值，^c为F值；与同组治疗前比较，^bP＜0.05。

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