留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

中青年营养状况与冠心病的关系

邓洁 刘晓明 卢微

邓洁, 刘晓明, 卢微. 中青年营养状况与冠心病的关系[J]. 中华全科医学, 2025, 23(11): 1834-1837. doi: 10.16766/j.cnki.issn.1674-4152.004239
引用本文: 邓洁, 刘晓明, 卢微. 中青年营养状况与冠心病的关系[J]. 中华全科医学, 2025, 23(11): 1834-1837. doi: 10.16766/j.cnki.issn.1674-4152.004239
DENG Jie, LIU Xiaoming, LU Wei. The relationship between nutritional status and coronary atherosclerotic heart disease in young and middle-aged people[J]. Chinese Journal of General Practice, 2025, 23(11): 1834-1837. doi: 10.16766/j.cnki.issn.1674-4152.004239
Citation: DENG Jie, LIU Xiaoming, LU Wei. The relationship between nutritional status and coronary atherosclerotic heart disease in young and middle-aged people[J]. Chinese Journal of General Practice, 2025, 23(11): 1834-1837. doi: 10.16766/j.cnki.issn.1674-4152.004239

中青年营养状况与冠心病的关系

doi: 10.16766/j.cnki.issn.1674-4152.004239
基金项目: 

河北省科技计划项目 20231798

详细信息
    通讯作者:

    刘晓明,E-mail:yuyan52001@qq.com

  • 中图分类号: R541.4

The relationship between nutritional status and coronary atherosclerotic heart disease in young and middle-aged people

  • 摘要: 近年来冠心病发病逐渐年轻化,35~45岁中青年人群发病增加尤为明显。中青年冠心病患者起病急,猝死风险高,预后更差。营养失衡已被确认是影响冠心病的主要危险因素之一,超过70%的冠心病住院患者有营养失衡风险。由于营养状况是目前通过行为干预重要的可改变因素,因此可作为冠心病的最佳干预目标。本文旨在总结使用控制营养状况(CONUT)评分评定的营养不良、微量营养素(尤其是维生素D、叶酸及维生素B12、锌、铁、硒)水平与冠心病之间的关系以及补充这些营养素对冠心病预后的影响。营养不良、微量营养素(尤其是维生素D、叶酸及维生素B12、锌、硒等)水平与冠心病预后显著相关。补充叶酸可改善心血管健康,但补充维生素D、维生素B12、锌等对心血管健康的有益影响尚存争议。出现这些相互矛盾的结果可能与人群特征、共病情况、心血管疾病类别、营养状况和营养补充方案有关。目前仍建议通过合理营养结合生活方式管理来预防心血管疾病,促进心血管健康。

     

  • [1] 孙佳艺, 邓秋菊, 郭默宁, 等. 2013—2019年北京市居民冠心病住院率变化趋势[J]. 首都公共卫生, 2021, 15(6): 326-329.

    SUN J Y, DENG Q J, GUO M N, et al. Trends of the hospitalization rates for coronary heart disease in Beijing from 2013 to 2019[J]. Capital Journal of Public Health, 2021, 15(6): 326-329.
    [2] 中国老年医学学会营养与食品安全分会, 中国医师协会营养医师专业委员会, 四川大学华西医院临床营养科, 等. 老年患者家庭营养管理中国专家共识(2024版)[J]. 中国循证医学杂志, 2025, 25(1): 1-23.

    Nutrition and Food Safety Branch of Chinese Geriatrics Society, Nutritional Physician Committee of Chinese Physicians Association, Department of Clinical Nutrition; West China Hospital, Sichuan University, et al. Chinese expert consensus on home nutrition administration for the elderly(2024 edition)[J]. Chinese Journal of Evidence-based Medicine, 2025, 25(1): 1-23.
    [3] 徐晶, 李小英. 父源性营养失衡与子代代谢重编程的机制研究进展[J]. 上海医学, 2024, 47(2): 112-116.

    XU J, LI X Y. Advances in mechanisms of paternal nutritional imbalance and metaolic reprogramming in offspring[J]. Shanghai Medical Journal, 2024, 47(2): 112-116.
    [4] POPIOLEK-KALISZ J, BLASZCZAK P. Nutritional status of coronary artery disease patients-preliminary results[J]. Int J Environ Res Public Health, 2023, 20(4): 3464. DOI: 10.3390/ijerph20043464.
    [5] 康云鹏, 郭雯, 任爱红, 等. 营养风险对老年射血分数减低型心力衰竭患者住院期间体适能的影响[J]. 中华全科医学, 2023, 21(6): 932-935, 944.

    KANG Y P, GUO W, REN A H, et al. Effect of nutritional risk on physical fitness during hospitalization in elderly patients with reduced ejection fraction heart failure[J]. Chinese Journal of General Practice, 2023, 21(6): 932-935, 944.
    [6] 盛虹, 章安迪. 慢性心力衰竭住院患者营养风险评估的临床应用研究[J]. 诊断学理论与实践, 2021, 20(2): 178-183.

    SHENG H, ZHANG A D. Study on application of nutritional risk screening in hospitalized patients with chronic heart failure[J]. Journal of Diagnostics Concepts & Practice, 2021, 20(2): 178-183.
    [7] ARERO G, ARERO A G, MOHAMMED S H, et al. Prognostic potential of the controlling nutritional status (CONUT) score in predicting all-cause mortality and major adverse cardiovascular events in patients with coronary artery disease: a meta-analysis[J]. Front Nutr, 2022, 9: 850641. DOI: 10.3389/fnut.2022.850641.
    [8] HUANG L J, HE L J, SUN X J, et al. Association of controlling nutritional status score with adverse outcomes in patients with coronary artery disease: a systematic review and meta-analysis[J]. Angiology, 2023, 74(2): 149-158. doi: 10.1177/00033197221094409
    [9] BANIK S, GHOSH A. Zinc status and coronary artery disease: a systematic review and meta-analysis[J]. J Trace Elem Med Biol, 2022, 73: 127018. DOI: 10.1016/j.jtemb.2022.127018.
    [10] Emerging Risk Factors Collaboration/EPIC-CVD/Vitamin D Studies Collaboration. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses[J]. Lancet Diabetes Endocrinol, 2023, 12(1): e2-e11. DOI: 10.1016/S2213-8587(23)00287-5.
    [11] 谢明慧, 梁冰, 金国玺, 等. 老年2型糖尿病合并营养不良患者与肌少症高风险的影响因素分析[J]. 中华全科医学, 2025, 23(1): 65-68, 121.

    XIE M H, LIANG B, JIN G X, et al. Analysis of factors influencing high risk of type 2 diabetes mellitus combined with malnutrition and sarcopenia in elderly patients[J]. Chinese Journal of General Practice, 2025, 23(1): 65-68, 121.
    [12] MIAO Y, GUO Y H, CHEN Y X, et al. The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis[J]. Nutr Rev, 2024, 82(10): 1386-1401. doi: 10.1093/nutrit/nuad127
    [13] BERGER M M, SHENKIN A, SCHWEINLIN A, et al. ESPEN micronutrient guideline[J]. Clin Nutr, 2022, 41(6): 1357-1424. doi: 10.1016/j.clnu.2022.02.015
    [14] VIRANI S S, NEWBY L K, ARNOLD S V, et al. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease: a report of the American heart association/American college of cardiology joint committee on clinical practice guidelines[J]. Circulation, 2023, 148(9): e9-e119. DOI: 10.1161/CIR.0000000000001168.
    [15] LIU J, HUANG Z D, HUANG H Z, et al. Malnutrition in patients with coronary artery disease: prevalence and mortality in a 46, 485 Chinese cohort study[J]. Nutr Metab Cardiovasc Dis, 2022, 32(5): 1186-1194. doi: 10.1016/j.numecd.2021.12.023
    [16] VOORTMAN T, CHEN Z L, GIRSCHIK C, et al. Associations between macronutrient intake and coronary heart disease (CHD): the rotterdam study[J]. Clin Nutr, 2021, 40(11): 5494-5499. doi: 10.1016/j.clnu.2021.08.022
    [17] 凌克玉, 郭子宁, 陈述凡, 等. 控制营养状态评分对脑卒中短期预后预测价值的Meta分析[J]. 医学研究杂志, 2024, 53(8): 34-41.

    LING K Y, GUO Z N, CHEN S F, et al. Meta-analysis of the predictive value of controlling nutritional status score for short-term prognosis of stroke[J]. Journal of Medical Research, 2024, 53(8): 34-41.
    [18] 中国营养学会健康管理分会. 维生素D营养状况评价及改善专家共识[J]. 中华健康管理学杂志, 2023, 17(4): 245-252.

    Health Management Branch of Chinese Nutrition Society. Expert consensus on evaluation and improvement of vitamin D nutritional status[J]. Chinese Journal of Health Management, 2023, 17(4): 245-252.
    [19] COSENTINO N, CAMPODONICO J, MILAZZO V, et al. Vitamin D and cardiovascular disease: current evidence and future perspectives[J]. Nutrients, 2021, 13(10): 3603. DOI: 10.3390/nu13103603.
    [20] 侯小丽, 吴述光, 潘静, 等. 2型糖尿病患者血清25-羟维生素D水平与代谢指标的相关性[J]. 新乡医学院学报, 2024, 41(11): 1043-1047, 1054.

    HOU X L, WU S G, PAN J, et al. Correlation between serum 25-hydroxyvitamin D level and metabolic indicators in patients with type 2 diabetes mellitus[J]. Journal of Xinxiang Medical University, 2024, 41(11): 1043-1047, 1054.
    [21] 李智, 赵莉, 郭娅娅. 单核细胞/高密度脂蛋白胆固醇比值及血清25羟维生素D水平与射血分数保留型心力衰竭患者易损期预后的相关性[J]. 广西医学, 2024, 46(11): 1651-1655.

    LI Z, ZHAO L, GUO Y Y. Correlation of monocyte-to-high density lipoprotein cholesterol ratio and serum 25 hydroxyvitamin D level with prognosis of patients with heart failure with preserved ejection fraction at vulnerable stage[J]. Guangxi Medical Journal, 2024, 46(11): 1651-1655.
    [22] THOMPSON B, WATERHOUSE M, ENGLISH D R, et al. Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial[J]. BMJ, 2023, 381: e075230. DOI: 10.1136/bmj-2023-075230.
    [23] SHIVKAR R R, GAWADE G C, PADWAL M K, et al. Association of MTHFR C677T (rs1801133) and A1298C (rs1801131) polymorphisms with serum homocysteine, folate and vitamin B12 in patients with young coronary artery disease[J]. Indian J Clin Biochem, 2021, 37(2): 224-231.
    [24] YUAN S, MASON A M, CARTER P, et al. Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study[J]. BMC Med, 2021, 19(1): 97. DOI: 10.1186/s12916-021-01977-8.
    [25] 中国临床合理补充叶酸多学科专家共识[J]. 医药导报, 2021, 40(1): 1-19.

    Consensus of Multidisciplinary Experts on the Rational Supplementation of Folic Acid in Chinese Clinical Practice[J]. Herald of Medicine, 2021, 40(1): 1-19.
    [26] GUO J C, LIU X X, WANG Z, et al. Methylmalonic acid, vitamin B12, and mortality risk in patients with preexisting coronary heart disease: a prospective cohort study[J]. Nutr J, 2023, 22(1): 63. DOI: 10.1186/s12937-023-00900-6.
    [27] 中华医学会肠外肠内营养学分会. 中国成人患者微营养素临床应用指南(2024版)[J]. 中华医学杂志, 2024, 104(11): 799-821.

    Chinese Society of Parenteral and Enteral Nutrition (CSPEN). Guidelines for clinical application of micronutrients in Chinese adult patients (2024 edition)[J]. National Medical Journal of China, 2024, 104(11): 799-821.
    [28] LU J X, HU Y C, LI M, et al. Zinc nutritional status and risk factors of elderly in the China adult chronic disease and nutrition surveillance 2015[J]. Nutrients, 2021, 13(9): 3086. DOI: 10.3390/nu13093086.
    [29] FIACCADORI E, SABATINO A, BARAZZONI R, et al. ESPEN guideline on clinical nutrition in hospitalized patients with acute or chronic kidney disease[J]. Clin Nutr, 2021, 40(4): 1644-1668. doi: 10.1016/j.clnu.2021.01.028
    [30] MENG H Y, WANG Y Y, ZHOU F F, et al. Reduced serum zinc ion concentration is associated with coronary heart disease[J]. Biol Trace Elem Res, 2021, 199(11): 4109-4118. doi: 10.1007/s12011-020-02551-8
    [31] NAZARI M, ASHTARY-LARKY D, NIKBAF-SHANDIZ M, et al. Zinc supplementation and cardiovascular disease risk factors: a GRADE-assessed systematic review and dose-response meta-analysis[J]. J Trace Elem Med Biol, 2023, 79: 127244. DOI: 10.1016/j.jtemb.2023.127244.
    [32] 中华医学会血液学分会红细胞疾病(贫血)学组. 铁缺乏症和缺铁性贫血诊治和预防的多学科专家共识(2022年版)[J]. 中华医学杂志, 2022, 102(41): 3246-3256.

    Red Cell Diseases (Anemia) Subgroup of Hematology Society, Chinese Medical Association. Multidisciplinary expert consensus on the diagnosis, treatment and prevention of iron deficiency and iron deficiency anemia(2022 edition)[J]. National Medical Journal of China, 2022, 102(41): 3246-3256.
    [33] LIU F L, LIU Y F, XU S H, et al. Mendelian randomization study reveals a causal relationship between serum iron status and coronary heart disease and related cardiovascular diseases[J]. Front Cardiovasc Med, 2023, 10: 1152201. DOI: 10.3389/fcvm.2023.1152201.
    [34] LANSER L, FUCHS D, SCHARNAGL H, et al. Anemia of chronic disease in patients with cardiovascular disease[J]. Front Cardiovasc Med, 2021, 8: 666638. DOI: 10.3389/fcvm.2021.666638.
    [35] 王新羽, 张霖柯, 符艾青, 等. 铁死亡在心血管疾病中的研究进展[J]. 中国现代医学杂志, 2022, 32(17): 61-66.

    WANG X Y, ZHANG L K, FU A Q, et al. Research progress of ferroptosis in cardiovascular disease[J]. China Journal of Modern Medicine, 2022, 32(17): 61-66.
    [36] GOSAVI R, JADHAV NB, NASHTE A. Intravenous iron technique evaluation in chronic heart failure with iron deficiency anemia[J]. Cureus, 2023, 15(10): e47778. DOI: 10.7759/cureus.47778.
    [37] SINGH B, BAJAJ N, SINGH P, et al. Iron deficiency in patients of heart failure with reduced ejection fraction[J]. Med J Armed Forces India, 2022, 78(4): 463-468. doi: 10.1016/j.mjafi.2022.04.013
    [38] 刘俊鑫, 魏源, 陈晨, 等. 中国9个长寿地区65岁及以上人群血硒水平与虚弱的关联研究[J]. 环境卫生学杂志, 2022, 12(1): 5-11.

    LIU J X, WEI Y, CHEN C, et al. Association of blood selenium levels with frailty in the older adults aged 65 years and above in nine longevity areas of China[J]. Journal Of Environmental Hygiene, 2022, 12(1): 5-11.
    [39] DABRAVOLSKI S A, SUKHORUKOV V N, MELNICHENKO A A, et al. The role of selenium in atherosclerosis development, progression, prevention and treatment[J]. Biomedicines, 2023, 11(7): 2010. DOI: 10.3390/biomedicines11072010.
    [40] AL-MUBARAK A A, BEVERBORG N G, SUTHAHAR N, et al. High selenium levels associate with reduced risk of mortality and new onset heart failure: data from PREVEND[J]. Eur J Heart Fail, 2021, 24(2): 299-307.
    [41] ALEHAGEN U, JOHANSSON P, SVENSSON E, et al. Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden[J]. Eur J Nutr, 2022, 61(6): 3135-3148. doi: 10.1007/s00394-022-02876-1
  • 加载中
计量
  • 文章访问数:  2
  • HTML全文浏览量:  2
  • PDF下载量:  0
  • 被引次数: 0
出版历程
  • 收稿日期:  2024-11-23
  • 网络出版日期:  2026-01-07

目录

    /

    返回文章
    返回